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KMID : 0382320060260010007
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Environmental Mutagens and Carcinogens
2006 Volume.26 No. 1 p.7 ~ p.11
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Screening of Antioxidative Effect of Combined Medicinal Plants on Oxidative Stress
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Kang Kyung-Ah
Hyun Jin-Won
Kang Dae-Gil
Kim Jin-Sook
Zhang Rui
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Abstract
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Reactive oxygen species (ROS) are known to cause oxidative modification of DNA, proteins, lipids and small cellular molecules and are associated with tissue damage and are the contributing factors for diabetes, inflammation, aging, cancer, arteriosclerosis, and hypertension. We screened the anti-oxidative effect on V79-4 hamster lung fibroblast cells induced by hydrogen peroxide with eleven extracts of combined medicinal plants. Dancheonhwankakambang and Samikangyabtang were found to show the scavenging activities of DPPH radical and intracellular reactive oxygen species, which is measured by dichlorodihydrofluorescin diacetate method (DCHF-DA).
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KEYWORD
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antioxidant, reactive oxygen species, V79-4 hamster lung fibroblast
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